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In Vivo Measurements With Glass Microelectrodes

Fumiro Suga, MD, DSc; Tsunehiko Nakashima, MD, DSc; James B. Snow, Jr., MD

Arch Otolaryngol. 1970;91(1):37-43.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN 1906, Cremer reported that when a thin glass membrane was interposed between two aqueous solutions, an electric potential difference was observed which was very sensitive to change in acidity.¹ Horovitz and Schiller later found that the introduction of boron oxide caused glass electrodes to become nearly as sensitive to Na⁺ as to H⁺.¹ In 1957, Eisenman et al^1,2 characterized the range of glass composition which had sufficiently high selectivities for Na⁺ or K⁺ to be practical for use in the measurement of Na⁺, on the one hand, or K⁺, on the other. Hinke^1,3,4 constructed Na⁺ and K⁺ glass microelectrodes to measure the intracellular activities of these cations. Khuri^1,5 further developed the cation sensitive microelectrode for biological use.

In 1954, Smith et al⁶ using a flame photometer reported that endolymph of the inner ear of the guinea pig had a high potassium and low . . . [Full Text PDF of this Article]

Author Affiliations
Oklahoma City

From the Department of Otorhinolaryngology, University of Oklahoma Medical Center, Oklahoma City.

Footnotes
Accepted for publication June 18, 1969.

Reprint requests to 800 NE 13th St, Oklahoma City 73104 (Dr. Snow).

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