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Fallacies of Preoperative Radiation
Frank Batley, MB, ChB
Arch Otolaryngol. 1968;87(5):456-460.
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THE AIMS of preoperative radiotherapy have been well publicized and are summarized as follows:
- With an "operable" tumor, malignant cells implanted at the operative site or spilled into the blood stream at the operation may be less likely to recur locally or metastasize.
- A tumor which would be ordinarily regarded as being on the border line of operability may be converted into an operable situation by the sterilization of the peripheral cells.
The experimental evidence for the latter statement is that the radiosensitivity of the cells is partly dependent on their oxygenation and, because the centers of malignant tumors tend to be anoxic, they are relatively radio-resistant. Therefore the peripheral cells which are well oxygenated respond better than the central cells. The hypothesis is that a course of radiotherapy could leave a central nidus of viable malignant cells which have been protected by their anoxic state and will
. . . [Full Text PDF of this Article]
Author Affiliations
Syracuse, NY
From the State University of New York, Upstate Medical Center, Syracuse, NY. Dr. Batley is now at Ohio State University Hospital, Columbus, Ohio.
Footnotes
Accepted for publication Oct 13, 1967.
Read before the Ninth Annual Meeting of the American Society for Head and Neck Surgery, Montreal, May 23, 1967.
Reprint requests to Radiation Therapy Department, Ohio State University Hospital, Columbus, Ohio 43210 (Dr. Batley).
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