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A Human Temporal Bone Report

Luiz F. Perez De Moura, MD; Royal C. Hayden, Jr., MD

Arch Otolaryngol. 1968;87(4):368-372.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SALICYLATE ototoxicity is considered a transient phenomenon; this has been known clinically^1-3 as well as being shown experimentally.^3,4 In the early literature, histologic (morphologic) evidence of the site of toxicity was confusing. Wittmaack⁵ in 1903 described the disappearance of Nissl bodies and changes in the nuclei of the spiral ganglion cells after quinine administration, and assumed salicylate effect would be similar. In 1913, Lindt⁶ was unable to confirm these findings. In 1938, Mosher⁷ described hemorrhage in the cochlea after quinine and salicylate toxicity in guinea pigs as seen in previous quinine studies by Kirchner⁸ in 1883, but he attributed these hemorrhages to temporal bone removal technique. In his monograph, Falbe-Hansen⁹ found Reissner's membrane depressed into the cochlear duct more often after salicylates or quinine than in untreated controls, especially when perfused with Wittmaack's fixatives. He interpreted this as evidence of hypotonic changes.

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Author Affiliations
Detroit

From the Otological Research Laboratory, Henry Ford Hospital, Detroit. Dr. De Moura is also affiliated with the Hospital Dos Servidores do Estado, Rio de Janeiro.

Footnotes
Accepted for publication Nov 27, 1967.

Reprint requests to 2799 W Grand Blvd, Detroit 48202 (Dr. Hayden).

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