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F. SCHOENHEYDER, MD; C. ZIMMERMAN-NIELSEN, MD; H. C. ANDERSEN, MD

Arch Otolaryngol. 1966;84(5):495-496.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE SYNDROME consisting of otosclerosis, blue sclerae, and fragility of bones (osteogenesis imperfecta) was described by Adair-Dighton¹ in 1912, and abnormal amino-aciduria has been detected in five patients with osteogenesis imperfecta by Chowers et al.² Arslan and Ricci³ and others have postulated that otosclerosis is a regional mesenchymopathy related to other connective tissue disorders. Among these diseases Kulonen and Kulonen⁴ found increased urinary elimination of some amino acids in rheumatoid arthritis. Prockop and Sjoerdsma⁵ observed increased urinary excretion of bound hydroxyproline in some cases of arachnodactylia (Marfan's syndrome), in which ill-defined defects in the connective tissue have been noted. We have therefore found it worthwhile to measure the amino-acid excretion in patients suffering from otosclerosis.

Material and Methods

Five patients with proven otosclerosis and three control subjects (nonotosclerotic patients) were studied.

Case 1.—This patient was a 44-year-old man with a history of progressive loss . . . [Full Text PDF of this Article]

Author Affiliations
AARHUS, DENMARK

From the Departments of Biochemistry and Otorhinolaryngology, University of Aarhus, Denmark.

Footnotes
Submitted for publication April 14, 1966.

Reprint requests to Aarhus Kommunehospital, Aarhus, Denmark (Dr. Andersen).

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