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CARL R. FEIND, MD

Arch Otolaryngol. 1966;83(2):105-108.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CHEMOTHERAPY in head and neck cancer had its clinical beginning in December 1942. Gilman and Philips,¹ Hunt and Philips,² and Goodman et al³ while studying top secret nitrogen mustard and its biological behavior at Yale University discovered its cytotoxic role when absorbed. Following extensive studies on animal tumors it was first used in man under the guidance of Gustav E. Lindskog. His first case was a radio-resistant terminal lymphosarcoma with massive involvement of the face, neck, mediastinum, and axilla. The tumor response was dramatic, only to be followed by severe bone marrow depression. As the bone marrow function returned, so did the tumor. This is indeed a familiar story to all of us who are working in this field 23 years later.

The alkylating agents were the first drugs to be used in an effort to destroy tumors by interfering with cell reproduction, but it was not . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Surgery, Columbia University, College of Physicians and Surgeons, and the Surgical Services of the Presbyterian Hospital, and Francis Delafield Hospital, New York.

Footnotes
Submitted for publication July 3, 1965.

Read before the joint meeting of the Triological Society and Section on Laryngology, Otology and Rhinology of the American Medical Association, New York, June 1965.

Reprint requests to 180 Ft. Washington Ave, New York 10032.

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