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III. Lactic Dehydrogenase in Vein Tissue

NATHANIEL SOIFER, MD; FRANZ ALTMANN, MD; GERALD L. ENDAHL, PhD; CHARLES HOLDSWORTH

Arch Otolaryngol. 1965;82(5):510-514.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

THREE different etiological factors are, as a rule, considered responsible for the development of otosclerosis: constitutional, local, and general.

The constitutional factor accounts for the heredity of the disease. The mode of inheritance is most probably a mono-hybrid autosomal dominant inheritance with a penetrance of the pathological gene of between 25% and 40%.¹

The local factors bringing about the exclusive involvement of the labyrinthine capsule and the characteristic distribution of the otosclerotic foci within the latter are considered to be of a developmental, circulatory, or mechanical nature. Their discussion would go beyond the scope of this paper.

Among the general activating factors, metabolic disturbances must be considered in the first place. However, no abnormalities were found in the lipoprotein,² calcium, phosphorus, cholesterol, or protein content of the blood serum,³ including the distribution of serum haptoglobins, the isoenzyme activity of serum esterase, and acid and alkaline phophatase . . . [Full Text PDF of this Article]

Author Affiliations
DAYTON, OHIO

From the Otological Research Laboratories, Good Samaritan Hospital (Dr. Soifer and Mrs. Holdsworth) Columbia University College of Physicians and Surgeons, New York (Dr. Altmann), Department of Physiological Chemistry and Department of Surgery, Ohio State University, Columbus (Dr. Endahl).

Footnotes
Submitted for publication April 29, 1965.

Reprint requests to PO Box 130, Davue Station, Dayton, Ohio 45406 (Dr. Soifer).

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