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ELIZABETH G. DOWDY, MD; NESRIN GOKSEN, MD; GODFREY E. ARNOLD, MD; WILLIAM T. MOORE, MD; LEONARD W. FABIAN, MD

Arch Otolaryngol. 1965;82(5):494-497.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Vestibular Depression by a Droperidol-Fentanyl Combination

JANSSEN has recently developed several analgesic and hypnotic drugs.¹ Two of these have been used in combination to produce an anesthetic state.^2-6 They are droperidol and fentanyl citrate (Innovar), with a droperidolfentanyl ratio of 50:1. One cubic centimeter of the mixture contains 0.05 mg fentanyl and 2.5 mg droperidol.

Fentanyl is a highly potent analgesic with a rapid onset and short duration of action. It possesses a weak emetic action and produces mild vagal stimulation. Droperidol belongs to an entirely new class of compounds known as butyrophenones. It produces sedation and a state of psychic detachment but leaves the patient able to cooperate intelligently on demand. Its onset is from five to ten minutes and lasts more than six hours. Droperidol possesses potent antiemetic properties and seems to protect against some ventricular arrhythmias. In combination these drugs produce an anesthetic condition that . . . [Full Text PDF of this Article]

Author Affiliations
JACKSON, MISS

From the Department of Anesthesiology and Division of Otolaryngology, Department of Surgery, University of Mississippi Medical Center.

Footnotes
Submitted for publication Sept 4, 1965.

Reprint requests to University of Mississippi Medical Center, School of Medicine 2500 N State St, Jackson, Miss 39216.

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