This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

MERLE LAWRENCE, PhD

Arch Otolaryngol. 1965;82(2):136-143.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

TEN years ago, in an effort to study the physiology of fully developed otic capsule bone in a way that would allow for observation of it as a living, changing, metabolizing tissue, we undertook to transplant into tissue-culture media the small bit of bone removed as a "cupola" from the surgical dome of the horizontal canal during fenestration surgery. A considerable outgrowth of cells resulted, originating apparently from the layer of osteogenic cells lying beneath the endosteal membrane removed with the fragment of bone. The characteristics and behavior of these cells were described in a paper read before the Otosclerosis Study Group in 1955.¹

None of these bone fragments appeared to have otosclerotic areas, but because they were removed from otic capsules that had otosclerosis nearby they could not, with certainty, be considered normal. However, this investigation demonstrated the feasibility of studying osteoblastic activity by tissue-culture methods and . . . [Full Text PDF of this Article]

Author Affiliations
ANN ARBOR, MICH

From the Kresge Hearing Research Institute, University of Michigan.

Footnotes
Submitted for publication Oct 27, 1964.

Reprint requests to University of Michigan Medical School, Kresge Hearing Research Institute, Ann Arbor, Mich.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?