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Cogan's SyndromeCase Presentations
LT. COL. JAMES P. ALBRITE, MC;
DAVID M. RESNICK, M.A.
Arch Otolaryngol. 1961;74(5):501-506.
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In 1945, David E. Cogan reported a symptom complex consisting essentially in the association of nonsyphilitic interstitial keratitis with vestibuloauditory dysfunction. This perplexing combination of symptoms is referred to as "Cogan's syndrome." At present, the cause is unknown and the treatment to date has not been consistently satisfactory.
Although Stevens18 documented a case of Cogan's syndrome occurring in a 10-year-old girl, the symptoms are most often seen in young adults. The ocular symptoms usually include redness and burning of the eyes, blurred vision, pain, lacrimation, and blepharospasm. The vestibuloauditory manifestations are vertigo, nausea, vomiting, and diminished hearing, closely resembling the symptomatology associated with Ménière's syndrome. With the onset of the hearing loss, the nausea, vomiting, and vertigo usually subside. The reduction in hearing acuity most often progresses to severe and permanent hearing loss.
Examination of the eye reveals a granular corneal infiltrate observable in the deeper layers of the
. . . [Full Text PDF of this Article]
Author Affiliations
USA; WASHINGTON, D.C.
Footnotes
Submitted for publication May 25, 1961.
Director, Army Audiology and Speech Center, Walter Reed General Hospital, Walter Reed Army Medical Center (James P. Albrite); Supervisor, Bioacoustic Section, Army Audiology and Speech Center, Walter Reed General Hospital, Walter Reed Army Medical Center (David M. Resnick).
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