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Local Use of Pancreatic Dornase

WALTER E. LOCH, M.D.

Arch Otolaryngol. 1961;73(6):686-688.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The use of antibiotics has done a great deal to minimize complications and to reduce chronicity of infections. Unfortunately the effectiveness of antibiotics is limited and occasionally even antibiotic-resistant strains of bacteria will develop. Additional means to either enhance the antibiotic effect or reduce inflammation are most desirable. With this thought in mind, pancreatic dornase has been used in infections of the paranasal sinuses.

The preparation used in this study is Dornavac* which is a stabilized preparation of the enzyme deoxyribonuclease, derived from beef pancreas.⁶

Rationale of Therapy

According to Sherry,¹ deoxyribonucleoprotein is an important constituent of puru- lent and inflammatory exudate and has been isolated in quantities ranging from 30%-70% of the total purulent sediment. It determines the character, viscosity, and amount of sediment in the exudate. Deoxyribonuclease is a pus-liquefying enzyme and is capable of degrading deoxyribonucleoprotein. The enzyme acts on extracellular fluids and disintegrating cells, . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Department of Otolaryngology, The Johns Hopkins School of Medicine.

Footnotes
Submitted for publication Sept. 18, 1960.

The pancreatic dornase (Dornavac) used in this study was furnished by Merck Sharp & Dohme Research Laboratories, West Point, Pa.

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