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Lethal Midline Granuloma— Wegener's Granulomatosis

IRVING M. BLATT, M.D; MERLE LAWRENCE, Ph.D.

Arch Otolaryngol. 1961;73(6):639-643.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The purpose of this paper is to describe the otologic features of fatal granulomatosis of the respiratory tract. Particular emphasis is placed upon the pathologic anatomic findings as seen in serial sections of the paired temporal bones of 2 patients with this disease.

Clinical Findings

Detailed clinical data concerning the University of Michigan Medical Center patients and selected cases from the literature have been presented previously.^1-12 The clinical otologic findings in this report are based upon a study of 18 patients of 124 previously reported, or 14.5% of total cases (Table). Five cases are from the University of Michigan series. The findings are essentially those of chronic middle ear and mastoid suppuration, often the result of salpingitis observed with nasopharyngeal granuloma formation. As is characteristic of Wegener's lethal midline granuloma complex in general, the otitic disease failed to respond to the conventional conservative or surgical therapeutic methods. In one . . . [Full Text PDF of this Article]

Author Affiliations
NEW ORLEANS

From the Department of Otolaryngology and the Physiological Acoustics Laboratory, University of Michigan Medical School, Ann Arbor.

Footnotes
Submitted for publication June 27, 1960.

Reported Cases of Fatal Respiratory Tract Granulomatosis with Otologic Manifestations

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