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IRVING M. BLATT, M.D.; HOLBROOKE S. SELTZER, M.D.; PHILIP RUBIN, M.D.; A. C. FURSTENBERG, M.D.; JAMES H. MAXWELL, M.D.; WILLIAM J. SCHULL, Ph.D.

AMA Arch Otolaryngol. 1959;70(6):707-757.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Fatal granulomatosis of the respiratory tract is a disease with a noteworthy natural history, recognizable clinical manifestations, and identifying pathologic characteristics. Men, women, and children of all ages are susceptible, many of whom have no previous stigmata of allergic or vascular disease.

The earliest reference to this disease appeared in 1897, when McBride1¹ reported bizarre ulcerative granulomatous lesions in "a case of rapid destruction of the nose and face." Similar cases have been reported by Fordyce,² Woods,³ Falchi,⁶ Chatellier,⁷ Kraus,⁸ Stewart,¹³ and others. In 1936 and 1939, Wegener^26,27 published three cases characterized by necrotizing granulomatosis of the nose, nasal accessory sinuses, larynx, and lungs associated with a "peculiar granulomatous nephritis." Wegener believed that the nose was the primary site of the disease and applied the term "rhinogenous granulomatosis" to the disease process.

A review of the available literature from 1897 to 1957 . . . [Full Text PDF of this Article]

Author Affiliations
Ann Arbor, Mich.

From the Departments of Otolaryngology, Radiology, and Human Genetics, University of Michigan Medical School and U.S. Veterans Administration Hospital.

Footnotes
Submitted for publication June 19, 1959.

Formerly Assistant Professor of Medicine, Department of Endocrinology and Metabolism, University of Michigan Medical School; now at U.S. Veterans Administration Hospital, 4500 S. Lancaster Road, Dallas 2, Texas (Dr. Seltzer). Present address of Dr. Rubin: Division of Radiotherapy, University of Rochester School of Medicine, Rochester 20, N. Y.

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