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An Experimental Study

J. H. T. RAMBO, M.D.

AMA Arch Otolaryngol. 1952;55(5):554-558.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SEVERAL while patients were being treated with cortisone and corticotropin (ACTH) for various diseases of mesenchymal tissues.¹ These clinical observations led to investigations to determine the effect of these hormones on the healing of experimental wounds. It was shown that when standard skin defects were made in rabbit ears the effect of cortisone caused a delay in the growth of all elements of connective tissue² and retarded the growth of granulation tissue in open wounds.³ When experimental fractures were made in rabbits, gross healing of the fractures and absorption of the hematomas were greatly delayed in the animals receiving cortisone.⁴ Additional studies on the effect of cortisone on induced open wounds in mice⁵ as well as incised wounds in rabbits 6 have also shown an inhibitory effect on wound healing. In man the effect of corticotropin on the healing of wounds in two patients was . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Lempert Institute of Otology, Lempert Research Foundation, Inc.

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