This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

MAURICE H. COTTLE, M.D.; J. ALLAN WEISS, M.D.; EDWARD POTTORFF, M.D.; EMANUEL HERZON, M.D.

Arch Otolaryngol. 1950;52(3):369-372.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

DURING the last few years there has been a widespread increase in the clinical use of hyaluronidase, the specific enzyme now generally conceded to be the "spreading factor" of Duran-Reynals¹ and McClean.² Various authors have reported its effectiveness in facilitating the absorption of fluids by hypodermoclysis³ and in effecting better local anesthesia in general surgery and dentistry⁴ and its effectiveness in ophthalmology⁵ and other varied clinical applications.⁶ We therefore decided to explore its possibilities in the field of rhinoplastic surgery.

Hyaluronic acid, a chemical gel, functions in tissues of the body as a cement substance between cells, thus acting as a barrier to the diffusion of tissue fluids. Hyaluronidase is the specific enzyme which hydrolyzes and depolymerizes hyaluronic acid,⁷ with the resultant lessening of the viscidity of the gel and consequent facilitation of diffusion of tissue fluids: The rate of diffusion is proportionate to the amount of enzyme available, and . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Departments of Otolaryngology, Cook County Hospital and Chicago Medical School.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?