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Correction with Dinenhydrinate ("Dramamine")

M. SCHIFF, M.D., M.Sc. (Med.); W. G. ESMOND, B.S.; H. E. HIMWICH, M.D., Ph.D.

Arch Otolaryngol. 1950;51(5):672-677.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

EXPERIMENTAL production of forced circling movements is well known, these movements having been elicited by means of anatomic lesions in numerous areas of the central nervous system. Muskens¹ produced such lesions by sectioning fibers of the posterior longitudinal fasciculus. Kennard and Ectors² reported forced circular movements after ablating area 8 of one frontal lobe. Mussen,³ on the other hand, obtained this effect by stimulating the red nucleus. Chemical alteration also may evoke compulsive behavior. Goldin and associates⁴ noted circling movements with the use of nitrogen mustards. Hill and associates⁵ observed similar behavioral changes in rats placed on diets deficient in manganese. However, the production of compulsory turning by a biochemical lesion was first observed by Freedman and Himwich,⁶ who elicited this response, called the adversive syndrome, by the intracarotid injection of di-isopropyl fluorophosphate, a drug which destroys cholinesterase and permits the accumulation of acetylcholine. . . . [Full Text PDF of this Article]

Author Affiliations
MEDICAL DVISION, ARMY CHEMICAL CENTER, MD.

From the Medical Division, Army Chemical Center, Maryland.

Footnotes
Read before the Section on Otolaryngology, College of Physicians, Philadelphia, on Jan. 18, 1950.

Thesis accepted by the faculty of the Graduate School of Medicine of the University of Pennsylvania in partial fulfilment of the requirements for the degree of Master of Medical Science [M. Sc. (Med.)] for graduate work in Otolaryngology.

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