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JOSEPH FREEMAN, M.D.

Arch Otolaryngol. 1950;51(2):237-244.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CHORDOMA is a fairly rare tumor derived from notochordal remnants, which are found along the craniosacrococcygeal axis. It is locally malignant. Most frequently it is found originating in the sacrum or cranium.¹ Its consideration in differential diagnosis of intracranial and nasopharyngeal tumors is sufficient reason to report a new case together with a brief outline of the nature of the tumor and the disease.

EMBRYOLOGY

A proper understanding of the nature of the tumor necessitates a brief discussion of the embryology of the notochord.²

The notochord has as its anlage a rodlike mesodermal structure, growing forward from a knob of cells at the head end of the primitive streak. This is a thickened band of ectoderm, which occupies the midplane of the embryonic disk. The latter is present at the end of the second week and is the result of the apposition of the floor of the early amnion sac . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Otolaryngological Service of Dr. Rudolph Kramer, Mount Sinai Hospital.

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