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Production of Protective Antibodies in Human Adults by the Oral Administration of Stock Polyvalent Bacterial Vaccines

JOHN A. KOLMER, M.D.; AMEDEO BONDI, Jr., Ph.D.; CLARE SCHILLINGER, B.S.

Arch Otolaryngol. 1949;50(6):693-699.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

AS PREVIOUSLY reported,¹ the oral administration to mice of stock polyvalent vaccines prepared from the desiccated organisms and their soluble products commonly involved in the secondary bacterial infections of the common cold has been found effective in the active immunization of some of these animals against virulent hemolytic streptococci, pneumococci of types I, II and III, Klebsiella pneumoniae and Staphylococcus aureus. The investigations of Thomson and Thomson² have also shown that such vaccines may be absorbed after oral administration to human beings, in whom agglutinins are then produced. Ross³ has likewise found that the oral administration of vaccines of pneumococci to human beings not only is well borne but quickly produces immunity, since protective antibodies against the type I pneumococcus were found in the serums of 75 per cent of subjects and against types II and III pneumococci in the serums of about 60 per cent. Thomson. . . . [Full Text PDF of this Article]

Author Affiliations
With the Technical Assistance of Anna M. Rule PHILADELPHIA

From the Department of Bacteriology and Immunology of Temple University School of Medicine and the Research Institute of Cutaneous Medicine.

Footnotes
This investigation was aided by a grant from the Wm. S. Merrell Company, Cincinnati, Ohio.

The present address of Dr. Bondi and Miss Schillinger is Hahnemann Medical College, Philadelphia.

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