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CIGARET SMOKE IRRITATIONIII. The Efficiency of Filters in Reducing Its Intensity
H. B. HAAG, M.D.;
J. K. FINNEGAN, Ph.D.;
P. S. LARSON, Ph.D.
Arch Otolaryngol. 1948;48(1):41-46.
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IN A RECENT publication1 we described in detail a method for the quantitative evaluation of the irritation which cigaret smoke causes as judged by its edema-producing properties, based on gravimetric determination of the increase of the moisture content of the upper palpebral conjunctiva of a rabbit's eye that has been exposed to cigaret smoke. The method is briefly as follows:
A smoking machine of the type described by Bradford, Harlan and Hanmer,2 which draws a 35 cc. puff once a minute, is used. Three puffs, as a rule, are directed through a suitable cup placed over the widely opened eye of the morphinized rabbit. When one eye only of each rabbit is exposed, the other serving as a control, we name the technic procedure A. When both eyes of each rabbit are exposed, thereby permitting comparison of two cigarets on the same animal, the technic is called procedure B. In
. . . [Full Text PDF of this Article]
Author Affiliations
RICHMOND, VA.
From the Department of Pharmacology, Medical College of Virginia.
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