This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

JULIUS WINSTON, M.D.

Arch Otolaryngol. 1948;47(6):746-751.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THAT STREPTOMYCIN when administered in daily doses of about 2 Gm. over a period of from two to twelve weeks may cause considerable damage to the vestibular apparatus was reported by Brown and Hinshaw,¹ Hinshaw, Feldman and Pfuetze² and Marden³ in 1946. Fowler and Seligman⁴ made a similar report in 1947.

Brown and Hinshaw expressed doubt as to whether the lesion is in the vestibular end organ or in the brain. In 1947 Skoog⁵ proved that Ménière's syndrome can be produced in a guinea pig by a lesion of the brain stem. It must, therefore, be observed that Ménière's syndrome may follow a lesion of the vestibular nuclei in the brain stem as well as a lesion of the peripheral end organ.

An analysis of the vestibular data obtained on 3 patients treated with streptomycin at the Hospital of the University of Pennsylvania forms the basis of this paper

CASE . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Section of Neuro-otology of the Department of Otolaryngology of the University of Pennsylvania School of Medicine.

Footnotes
Read before the Section on Otolaryngology of the College of Physicians of Philadelphia, Feb. 19, 1947.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?