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A Clinical and Experimental Study

FRANK J. OTENASEK, M.D.; DAVID FAIRMAN, M.D.

Arch Otolaryngol. 1948;47(1):21-28.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

TYROTHRICIN, a bactericidal substance, has been known since 1939, when it was first discovered by Dubos,¹ who the following year² elaborated on its effect in experimental bacterial infections. His description was rapidly followed by numerous clinical trials, which have been enthusiastically recorded in the medical literature from 1941 to the present time. Its effectiveness when it is used locally in the treatment of infections of the nasal sinuses and the mastoid process has been repeatedly pointed out by Crowe and his associates.³ The toxic and the pharmacologic properties of the new agent were early studied by Herrell and Heilman,⁴ Rammelkamp and Weinstein⁵ and Robinson and his associates.⁶ In general, the material was shown to be markedly toxic (mostly by hemolysis) when used intravenously or by other injection method. In animal experiments its use was limited to surface application, on infected areas, or to irrigation of infected body cavities. It was . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Department of Surgery (Neurosurgery), Johns Hopkins University and Hospital.

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