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GEORGE S. LIVINGSTON, M.D.; EDWARD R. NEARY, M.D.

Arch Otolaryngol. 1948;47(1):1-6.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE PROTHROMBINOPENIC effect of acetylsalicylic acid and the salicylates and the protective action of vitamin K, administered with these drugs, have been demonstrated by a number of investigators.¹ The clinical significance of these findings has presented an importunate problem for study, particularly with reference to whether in man salicylate-induced prothrombinopenia is of sufficient magnitude to cause hemorrhage. In this regard, Quick² has stated that the blood prothrombin must be reduced below 20 per cent of normal before there is danger of hemorrhage and that salicylates, even when given in massive doses, do not cause the prothrombin to fall to the hemorrhagic level.

Quick's view seems to have been confirmed by the more recently reported results of extensive studies made by the Armed Forces, in which large numbers of patients with rheumatic fever were treated with massive doses of salicylates. Coombs and collaborators³ followed salicylate blood levels in 48 Army patients . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO; NEWARK, N. J.

From the Otho S. A. Sprague Memorial Institute Laboratory, Children's Memorial Hospital, Chicago (Dr. Livingston), and the Medical Department, White Laboratories, Inc., Newark, N. J. (Dr. Neary).

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