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John F. Delph, M.D.; Walter H. Theobald, M.D.

Arch Otolaryngol. 1946;44(2):246-251.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Sulfonamide Toxicity: Interpretation of Laboratory Findings. Presented by DR. I. DAVIDSOHN.

Laboratory tests properly interpreted may help in the avoidance of serious complications in the course of sulfonamide therapy: The finding of sulfonamide crystals in the urine is of little consequence. Microscopic hematuria should focus attention on the adequacy of fluid intake and output, and on other possible impending complications, but does not of itself require interruption of therapy.

In the presence of gross hematuria, sulfonamide therapy should be stopped immediately.

The chemical reaction of the urine should be watched in patients receiving alkalis.

Blood counts and differential studies should be made at reasonable intervals. A blood count prior to initiation of therapy may help to evaluate subsequent findings.

Leukopenia is not a contraindication to sulfonamide therapy, nor is a leukopenia down to about 3,500 white blood cells when it develops in the course of treatment. Severe granulopenia is an . . . [Full Text PDF of this Article]

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