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Clinical and Bacteriologic Studies with Special Reference to Topical Applications

ELIZABETH DeBLOIS, M.D.

Arch Otolaryngol. 1946;44(2):174-183.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A NUMBER of otolaryngologic cases in which penicillin was injected intramuscularly and applied topically were followed by me over a period of one year, from February 1944 to February 1945.

Much has been written recently in the literature about penicillin, but little has been said regarding the topical application of the agent in otolaryngologic cases or of the bacteriologic aspects of these cases in relation to the clinical work. Penicillin has been found to be effective in the presence of pus, peptones, tissue autolysates and other substances that are inhibitory of sulfonamide compounds.¹

Penicillin is essentially nontoxic, and the toxic reactions attributed to it were apparently due to toxic impurities rather than to penicillin.²

Lierle and Evers³ have shown that penicillin has practically no irritating effect on the cilia of the nasal mucosa, even when the concentration of penicillin is as high as 5,000 Oxford units per cubic centimeter of . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary.

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