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ELDON M. BOYD, M.D., C.M.; JOAN COPELAND, B.A.; FREDERICK H. LAPP, M.D.

Arch Otolaryngol. 1946;44(2):166-173.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE LOCAL use of decongestive agents in the nose has been popular for many years in the symptomatic treatment of a "running nose" or "stuffed-up nose" in allergic rhinitis, catarrhal rhinitis and allied conditions. At present, the most commonly used drugs are sympathomimetic amines, such as amphetamine or ephedrine or neosynephrine hydrochloride. Sympathomimetic amines which are volatile at room temperature, such as amphetamine, may be applied as inhalers, which is a convenient form of medication. A nonvolatile drug, or one nonvolatile at room temperature, is usually converted into the watersoluble hydrochloride or sulfate and used as "drops" or sprayed on the congested mucosa with the aid of a nebulizer. A similarly acting drug, chemically related to histamine, is 2-naphthyl-methyl imidazoline hydrochloride (privine hydrochloride). In recent years, a third group has been introduced, chemically being aliphatic amines, of which tuamine, (2-aminoheptane) is an example. Tuamine has the advantage that it is . . . [Full Text PDF of this Article]

Author Affiliations
KINGSTON, ONTARIO, CANADA

From the Department of Pharmacology, Queen's University. This work was aided financially by grants from the Banting Research Foundation and from Eli Lilly and Company.

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