This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

GEORGE KELEMEN, M.D.; FREDERICK SARGENT, B.S.

Arch Otolaryngol. 1946;44(1):24-42.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

INVESTIGATIONS of the effects of drugs on the mucous membranes of the nose have been encouraged by the fact that in various laboratory animals the nasal mucous membranes are easily accessible for such study and the effects of the drugs can be observed without the function of other vital organs being interfered with.

The basis for this type of experiment is complete orientation as to (1) the normal anatomy and histology of the animal in question and (2) knowledge of pathologic conditions as they are encountered spontaneously, i.e., in the course of the normal life under laboratory conditions or in the animal farms of the institutions without exposure to experimental factors. Rabbits are generally preferred in such work, but dogs, cats, mice, rats, ferrets and monkeys are frequently used.

Two groups of drugs are examined by this assay: (1) medicaments used locally in the treatment of nasal conditions and (2) . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Department of Otolaryngology, Tufts College Medical School, and the Massachusetts Eye and Ear Infirmary.

Footnotes
This investigation was aided by grants of the Charlton Fund, Tufts College Medical School, and of Wallace and Tiernan Products, Inc.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?