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MAJOR F. J. PUTNEY

Arch Otolaryngol. 1945;41(4):247-251.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The clinical use of penicillin in the treatment of diseases of the ear was first reported by Florey and Florey¹ in March 1943. They reported 22 cases of mastoiditis in which the patients were treated postoperatively by local instillation of penicillin. I have used penicillin clinically at Bushnell General Hospital since April 1943, and it is the experience gained from this treatment of various otologic diseases on which this paper is based.

In this series of 10 cases of mastoiditis and its complications, the organisms, either streptococci or staphylococci, were found to be sensitive to penicillin, and their growth was inhibited by 0.1 unit or less of penicillin per cubic centimeter on culture. None of the causative bacteria in these cases became resistant to the drug. In my experience, failure of organisms to respond to penicillin has proved to be due to a resistant bacterial strain. When, after three or . . . [Full Text PDF of this Article]

Author Affiliations
MEDICAL CORPS, ARMY OF THE UNITED STATES

From the Ear, Nose and Throat Unit of the Surgical Service, Bushnell General Hospital, Brigham City, Utah.

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