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GILBERT N. HAFFLY, M.D.; LLOYD A. SCHIPFER, M.D.

Arch Otolaryngol. 1940;31(5):858-862.

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Otolaryngologic literature is singularly devoid of references to clinical signs of leukemic disease manifesting itself primarily in the nasal passageways. It appears that the pathologic condition necessary to cause such symptoms is comparatively rare. In 1932 the late Dr. Richard H. Jaffé,¹ renowned pathologist, stated, "I have never seen leukemic infiltrations of the mucosa of the nose. I think that they are extremely rare, although they have been reported."

Various writers have described leukemic involvement of the mucous membrane of the nasal passages and the paranasal sinuses. However, the pathologic changes presented appear meager compared with the clinical signs encountered in the present case.

In his classic monograph, "Leukemia and Allied Disorders," Forkner² pointed out in the section on leukemic manifestations of the upper respiratory tract that the mucous membranes of the mouth and the upper respiratory tract are the site of several kinds of lesion, which, like those in . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

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