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NOAH FOX, M.D.

Arch Otolaryngol. 1931;13(1):73-76.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In chronic nasal obstructive diseases it is frequently necessary to prescribe solutions of epinephrine and ephedrine over a period of time. This is particularly true in chronic conditions of the sinuses as well as in the various cases of vasomotor rhinitis encountered in ordinary practice. Whether or not these drugs, acting as a palliative in the beginning, are deleterious after long usage, is a matter deserving investigation.

In another paper,¹ I report what appears histologically to be an injury to the nasal vasculosa of animals sprayed only once with a 1:1,000 solution of epinephrine, while no such injury is apparent in animals sprayed with a 1: 50 solution of ephedrine. The purpose of these experiments is to note the effect of these drugs on the nasal mucosa of rabbits after daily usage over a long period of time. A 1: 1,000 solution of epinephrine chloride and a 1: 50 . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Pharmacology and Anatomy, University of Chicago.

Footnotes
Submitted for publication, Sept. 12, 1930.

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