This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Merrill A. Biel, MD, PhD
Minneapolis, Minn

Arch Otolaryngol Head Neck Surg. 1997;123(8):888.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The concerns that Dilkes and McGilligan have raised are certainly real and are the same concerns that I had before treating patients with intraoperative adjuvant PDT using porfimer sodium.

It is critical that proper preclinical animal studies be performed before PDT is used in humans to determine the appropriate light and drug doses that cause minimal or no damage to normal tissue. In most cases, the results found in small rodent models do not approximate the results found in humans. Likewise, each photosensitizer behaves differently and must be evaluated separately. In experiments in my laboratory using the dog as a model, in which the response is closely approximated with that seen in humans,¹ PDT using porfimer sodium, 2 mg/kg intravenously, followed by 50J/cm² at 150 mW/cm² of 630-nm light 48 hours later, caused no intrinsic damage to large arteries in the neck, including the carotid . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?