This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

David I. Smith, PhD; Maria del Mar Alonso, CLS

Arch Otolaryngol Head Neck Surg. 1993;119(11):1210-1216.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Objective:

The homozygous inactivation of tumor suppressor genes is a common event in the multistep process of tumorigenesis. The identification of most tumor suppressor genes known to date has come from the study of individuals with a defective copy of such a gene that increases their predisposition to malignancy. Although much is still to be learned about the function of these genes, they all seem to play a role in cell growth regulation. Karyotypic and molecular studies of several solid tumors suggest the presence of at least three tumor suppressor genes on the short arm of human chromosome 3. We present an overview on the progress made in the identification of tumor suppressor genes involved in solid tumor development.

Conclusion:

The explosive effort to map the human genome fueled by the Human Genome Project will facilitate the identification of tumor suppressor genes on chromosome 3 and on other chromosomes within . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Molecular Biology and Genetics, Wayne State University School of Medicine, Detroit, Mich.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?