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HAYES H. WANAMAKER, MD; JOHN M. FLANZER, MD; HERBERT SILVERSTEIN, MD
Sarasota, Fla

Arch Otolaryngol Head Neck Surg. 1991;117(3):340.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—Diuretic therapy is a mainstay in the medical treatment of Meniere's disease.¹ In our practice, as well as in many other large otologic practices, the drug of choice has been a fixed combination of hydrochlorothiazide and the potassium-sparing diuretic triamterene (Dyazide). Because of concern regarding the possible effect of this therapy on cholesterol and glucose metabolism, our internal medicine consultants recently advised us to switch our patients' therapy to indapamide (Lozol), a new oral antihypertensive/diuretic reported to have only a "slight"² effect on serum potassium levels.

Shortly after changing our patients' therapy to this medication, we began to receive numerous laboratory reports of hypokalemia, as well as calls from patients complaining of its characteristic symptoms (weakness, fatigue, and lethargy). In all cases, symptoms promptly resolved and potassium levels stabilized with resumption of therapy with hydrochlorothiazide and triamterene.

We wish to alert the otolaryngologic community to . . . [Full Text PDF of this Article]

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