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MICHAEL F. PRATT, MD
Norfolk, Va

Arch Otolaryngol Head Neck Surg. 1991;117(1):17.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

At the annual meeting of the American Academy of Otolaryngology–Head and Neck Surgery, San Diego, Calif, September 1990, David E. Eibling et al, San Antonio, Tex, presented their work with tumor-infiltrating lymphocytes in locally advanced squamous cell carcinoma of the head and neck.

Twenty-two patients with advanced squamous cell carcinoma of the head and neck were studied for a minimum of 30 months. Correlation between in situ characteristics of tumor-infiltrating lymphocytes and recurrent disease was investigated. At the time of surgery, tumor specimens were collected, snap frozen, and stained with immunoperoxidase. Monoclonal antibodies were used for identification and classification. A variety of head and neck sites were included in the study. Lymphocytes with the CD4⁺ marker were predominant in the parenchyma of tumors.

Twelve patients (55% ) developed recurrent disease from 4 to 18 months after therapy. There was a significant difference in recurrence rates between patients having greater than 20 . . . [Full Text PDF of this Article]

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