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SHAN R. BAKER, MD

Arch Otolaryngol Head Neck Surg. 1988;114(6):621.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In an effort to preserve laryngeal function in patients with carcinoma of the larynx, Wolf et al reported on a new strategy in treatment at the recent Second International Head and Neck Oncology Research Conference held in Arlington, Va.

In 1985, the Veterans Administration cooperative study program initiated a prospective, randomized multi-institutional study of the effectiveness of induction chemotherapy (CT) and radiation therapy (RT) compared with surgery and postoperative RT in patients with stage III/IV laryngeal squamous carcinoma. Induction CT (cisplatin, 100 mg/m² administered intravenously on day 1, and fluorouracil, 1000 mg/m² in a 24-hour infusion on days 1 through 5) was repeated on days 1, 22, and 43. Tumor response was assessed after two cycles; responders received a third cycle followed by tumor biopsy and RT (66 to 76 Gy [6600 to 7600 rad]). Patients having less than a partial response (PR) had salvage laryngectomy and RT. . . . [Full Text PDF of this Article]

Author Affiliations
Ann Arbor, Mich.

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