
Thyroid Suppression and Radioiodine Treatment for Differentiated Thyroid Cancer
HELMUTH RÖSLER, MD
Bern, Switzerland
Arch Otolaryngol Head Neck Surg. 1987;113(7):778.
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To the Editor.—In his article about therapy for differentiated thyroid cancer, Dunn describes the benefits of treating patients who have differentiated thyroid carcinomas with exogenous thyroid hormones and compares this treatment with radioiodine therapy. He maintains that "the value and optimal application of this [radioiodine] therapy remain controversial" and that "a satisfactory controlled investigation still needs to be done." On the other hand, he explains the effect of exogenous thyroid hormones as being due to a reduction in the level of thyrotropin, which "may be an important growth factor" in these tumors.
To my knowledge, there is not a single patient described in the literature in whom a primary tumor or a histologically proved metastasis of a differentiated thyroid carcinoma regressed in size or even ceased to grow under treatment with thyroid hormones alone. The explanation given by the author for those well-differentiated cancers that "hypersecrete thyroid hormone and
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