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MARK C WEISSLER, MD
Chapel Hill, NC

Arch Otolaryngol Head Neck Surg. 1987;113(1):17.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

At the September 1986 meeting of the American Academy of Otolaryngology—Head and Neck Surgery in San Antonio, Tex, Dr Jonas T. Johnson and colleagues reported the results of a multicenter, prospective, randomized study of one day vs five days of prophylactic cefoperazone therapy in 109 patients undergoing high-risk contaminated head and neck surgery requiring myocutaneous flap reconstruction. Patients were accrued from the University of Pittsburgh, Ohio State University, the University of Cincinnati, the University of Arkansas, and the Wilford Hall US Air Force Medical Center.

Of 53 patients receiving one day of perioperative antibiotics, 13 (18.9%) developed wound infections, while 14 (25%) of 56 patients receiving five days of perioperative antibiotic prophylaxis developed wound infections. These differences were not significant, and Dr Johnson concluded that no additional benefit was obtained by the administration of prophylactic antibiotics for more than 24 hours postoperatively in patients undergoing major head and neck surgery . . . [Full Text PDF of this Article]

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