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  Vol. 135 No. 9, September 2009 TABLE OF CONTENTS
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  •  Online Features
  Clinical Problem Solving: Pathology
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 •Pathology of Head & Neck
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Pathology Quiz Case 1: Diagnosis

Arch Otolaryngol Head Neck Surg. 2009;135(9):946-947.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Keratocystic odontogenic tumor (KCOT)

The odontogenic keratocyst (OKC) is a unique type of odontogenic cyst. The current nomenclature recommended by the World Health Organization is KCOT, because it better reflects the neoplastic nature of the lesion than the previously used term OKC.1 The KCOT is locally aggressive because it has a high mitotic activity and epithelial turnover rate, prostaglandin-induced bone resorption, and active collagenases in the fibrous cystic wall. These characteristics lead to its potential for local destructive behavior, its propensity for recurrence, and its tendency to multiply, especially when it is associated with nevoid basal cell carcinoma syndrome (Goltz-Gorlin syndrome).1-2

The KCOT has a peak incidence in the second and the third decades of life, with a slight male predilection. It has a predilection for the posterior part of the mandible and presents as a unilocular or multilocular radiolucent lesion of the jaw. It is believed that KCOT arises from cell . . . [Full Text of this Article]



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RELATED ARTICLE

Pathology Quiz Case 1
Poramate Pitak-Arnnop, André Chaine, Kittipong Dhanuthai, Jacques-Charles Bertrand, and Chloé Bertolus
Arch Otolaryngol Head Neck Surg. 2009;135(9):944.
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