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Arch Otolaryngol Head Neck Surg. 2009;135(7):722.

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Diagnosis: Coexistent conventional mucoepidermoid carcinoma of the thyroid (MECT) and papillary thyroid carcinoma

While mucoepidermoid carcinoma is one of the most common salivary gland cancers, it rarely originates in the thyroid. To date, approximately 40 cases of MECT have been reported.^1-4 There are 2 distinct subtypes of MECT: conventional MECT and sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE). Each subtype has a distinctive clinicopathologic presentation: SMECE more frequently affects women, often around the age of 60 years.¹ It appears histologically as a dense fibrosclerotic stroma infiltrated with nests of mucin and squamous cells as well as abundant eosinophils and scattered lymphocytes, and it invariably occurs in a background of chronic lymphocytic thyroiditis.² In contrast, conventional MECT, which is histologically similar to mucoepidermoid carcinoma of salivary origin, affects a slightly younger age group and does not have a sex predilection. It is composed of 3 distinct types of cells (squamoid, mucous, and intermediate), which are arranged in mucin-containing cysts and solid epithelial nests. Intracytoplasmic mucin . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2009;135(7):720.
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