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Impact on Perioperative and Long-term Complications

Richard O. Wein, MD

Arch Otolaryngol Head Neck Surg. 2009;135(6):597-601.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Hypothesis: Smoking cessation at the time of diagnosis with an upper aerodigestive tract squamous cell carcinoma minimizes perioperative morbidity and improves long-term outcome.

BACKGROUND

Habitual tobacco use is the leading preventable cause of death in the United States and is responsible for 1 of every 5 deaths.¹ Although there has been a steady decline in the percentage of smokers since 1960, a plateau in this progress has been noted in the past decade. In 2000, 25.7% of males and 21.0% of females were smokers.² The physiologic impact of smoking is well described and includes impaired mucus transport and pulmonary macrophage function, increased bronchial reactivity and arterial carbon monoxide levels, reduced oxygen transport, and inhibited mitochondrial oxidative metabolism.³ In addition, active smoking, including heavy (20 cigarettes/d) and lighter users, has also been associated with an increased relative risk (1.44 overall) of the future development of type 2 . . . [Full Text of this Article]

PRO

Second Cancers and Recurrence

Wound Healing and Perioperative Impact

CON

Second Cancers

Perioperative Impact

Wound Healing

BOTTOM LINE

AUTHOR INFORMATION

Author Affiliation: Department of Otolaryngology–Head and Neck Surgery, Tufts Medical Center, Boston, Massachusetts.

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