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Surgical Oncology in the Genomic Era

Gregory T. Wolf, MD

Arch Otolaryngol Head Neck Surg. 2009;135(4):337-341.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

The next decade will be one of the most exciting, challenging, and, perhaps, unsettling eras in head and neck surgical oncology. We can expect surgical dogma and traditional oncologic principles to be challenged in every aspect. These challenges will be raised by experienced colleagues who have observed the evolution of our understanding of tumor behavior and the limitations of conventional surgery, radiotherapy, and chemotherapy. New questions will be raised because of increasing knowledge of the basic biological characteristics of carcinogenesis, cellular proliferation, and immune homeostasis. How should we prepare ourselves and the next generation of surgical oncologists for these challenges? I believe that we are at a critical crossroads in head and neck oncology between a well-worn highway of surgical technique and a newer roadway of tumor biology and molecular medicine. The obvious main roadway will lead to superb technical advancements in areas such as free . . . [Full Text of this Article]

HYPOTHESIS

THE CHALLENGE TO SURGEONS

PARADIGM 1: TREATMENT SELECTION

PARADIGM 2: BIOLOGICAL STAGING

PARADIGM 3: MOLECULAR RISK ASSESSMENT

A NEW TRADITION AND TEAM

AUTHOR INFORMATION

Author Affiliation: Department of Otolaryngology, University of Michigan, Ann Arbor.

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