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  Vol. 135 No. 3, March 2009 TABLE OF CONTENTS
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  •  Online Features
  Clinical Problem Solving: Pathology
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 •General Rhinology
 •Neoplasms of Head & Neck
 •Pathology of Head & Neck
 •Pediatric Otolaryngology
 •Salivary Gland Disorders
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Pathology Quiz Case 1: Diagnosis

Arch Otolaryngol Head Neck Surg. 2009;135(3):322.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Salivary gland anlage tumor (SGAT)

Salivary gland anlage tumors are rare causes of nasal obstruction in neonates. Previously classified as a congenital pleomorphic adenoma by Har-El et al,1 these lesions were definitively characterized by Dehner et al,2 who described a series of 9 patients in 1994. A total of 23 cases have been reported in the literature to date.1-9 The histologic appearance of SGAT is characterized by fusiform, epithelioid proliferations that merge with ductal and glandular structures that are often lined by cuboidal, "basaloid" cells. These internal structures are focally continuous with the squamous mucosa of the tumor's surface.4 Similar structural organization and cellular composition are evident during the embryological development of salivary glands when the ectoderm or endoderm proliferates into the underlying mesenchyme.2 Debate regarding whether SGAT is a hamartoma or a true neoplasm remains unresolved. However, its attempts to recapitulate salivary gland development, its midline location, and its benign nature tend to favor . . . [Full Text of this Article]



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RELATED ARTICLE

Pathology Quiz Case 1
Marc W. Herr, Stephen B. Williams, and Benjamin B. Cable
Arch Otolaryngol Head Neck Surg. 2009;135(3):320.
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