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Arch Otolaryngol Head Neck Surg. 2008;134(9):1014.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Schwannoma with ancient change

Histologic examination showed proliferation of uniform spindle cells near the deep margin of the biopsy specimen (Figure 3), as well as areas with similar spindle cells more loosely arranged amid a myxoid background with occasional nuclear pleomorphism and hyperchromasia, representing degenerating cells (Figure 4). Such degenerative characteristics have been termed ancient change.^1-2 The tumor cells stained diffusely positive with S100 protein. Ancient change was originally coined by Ackerman and Taylor² to denote hypercellularity, nuclear pleomorphism, hyperchromasia, and degenerative changes that were thought to represent the prolonged course of these tumors. Such changes can be suggestive of malignancy initially, but thorough examination of the specimen will confirm a lack of mitotic activity and demonstrate a well-defined capsule without invasion of surrounding tissue.³

Figure appears in full text version. Figure 3.

Figure appears in full text version. Figure 4.

Given the young age of the patient and the benign diagnosis in the present case, no further surgery was . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2008;134(9):1012.
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