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Lymph Node Status Cannot Be Ignored in Survival Analysis of Laryngeal Cancer
Shilpa S. Chatni, MS, MRCSEd;
Krishnakumar Thankappan, MS, DNB
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The article by Chen and Halpern1 presents a good way of assessing the actual outcome of laryngeal cancer in a population following treatment modifications adopted based on level I evidence from clinical trials. The study actually looked at the outcome in a large sample of patients with laryngeal cancer over a long follow-up period. However, we have 2 reservations regardng the way the analysis was performed and the conclusions that were drawn from the analysis.
The analysis compares survival in specific subgroups of patients with laryngeal cancer who were treated with 3 different treatment modalities: radiotherapy, chemoradiotherapy, and surgery followed by radiotherapy. The different subgroups that were analyzed were stage III laryngeal cancer patients, stage IV laryngeal cancer patients, both stages III and IV laryngeal cancer patients together, and patients with T3 disease. A significantly low survival rate was shown for . . . [Full Text of this Article]
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RELATED ARTICLE
Factors Predictive of Survival in Advanced Laryngeal Cancer
Amy Y. Chen and Michael Halpern
Arch Otolaryngol Head Neck Surg. 2007;133(12):1270-1276.
ABSTRACT
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RELATED LETTER
Lymph Node Status Cannot Be Ignored in Survival Analysis of Laryngeal Cancer—Reply
Amy Y. Chen and Michael T. Halpern
Arch Otolaryngol Head Neck Surg. 2008;134(7):786-787.
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