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Pathology Quiz Case: Diagnosis
Arch Otolaryngol Head Neck Surg. 2008;134(7):784-785.
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Diagnosis: Nasal hamartoma, fibroglandular type
Hamartoma describes a lesion composed of disorganized but mature specialized cells that are indigenous to the particular site.1 Hamartomas are thought to arise from anomalous development and, unlike neoplastic lesions, are incapable of unimpeded growth. They commonly originate in the lungs, kidneys, and intestines but are uncommon elsewhere in the body and are seldom found in the nasal cavity and paranasal sinuses.2
Hamartomas are often found incidentally on radiographic imaging; however, patients may present because of the mass effect and focal damage to surrounding structures. In the nose and paranasal sinuses, symptoms attributable to this mass effect may include nasal obstruction, epiphora, recurrent sinusitis, rhinorrhea, or epistaxis. Diagnostic workup of an intranasal mass requires a thorough head and neck examination with endoscopy, computed tomography, and biopsy. Identification of a hamartoma by small biopsy fragments is difficult, as in the index case, but a long history, tissue arrangement, bland cytologic characteristics, . . . [Full Text of this Article]
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Pathology Quiz Case
Jonathan G. Thomas, Oscar B. Lahoud, P. Daniel Ward, Jonathan B. McHugh, and Melissa A. Pynnonen
Arch Otolaryngol Head Neck Surg. 2008;134(7):783.
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