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Arch Otolaryngol Head Neck Surg. 2008;134(4):448-449.

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Diagnosis: Atypical meningioma with clear cell features (World Health Organization [WHO] grade II)

Meningiomas are a heterogeneous group of central nervous system tumors arising from the arachnoidal cap cells of the meninges, and they represent approximately 15% to 20% of all primary intracranial neoplasms.¹ The WHO currently recognizes 13 histologic subtypes.² Clear cell meningioma is an uncommon variant, representing approximately 0.2% of all meningiomas.³ It is most commonly found in the spinal or cerebellopontine region and usually affects younger patients. This histologic subtype shows aggressive behavior, with a high recurrence rate, and distant metastasis, though rare, has been reported.⁴

Clinically, most patients with a meningioma present with headache, focal seizures, progressive spastic weakness, dysphasia, or focal motor or sensory symptoms. In approximately 2% of meningioma cases, the maxillofacial skeleton is involved, and patients may develop symptoms and clinical findings referable to obstruction of sinus ostia outflow, mass effect of tumor on the orbit or sinuses, or direct invasion into adjacent structures. The presence . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2008;134(4):447.
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