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Arch Otolaryngol Head Neck Surg. 2008;134(4):448.

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Diagnosis: Oncocytic lipoadenoma of the parotid gland

The differential diagnosis of oncocytic neoplasms of salivary glands includes both primary and metastatic tumors.¹ Oncocytic cells have small, round, centrally placed nuclei with abundant granular eosinophilic or clear cytoplasm that demonstrates numerous mitochondria on ultrastructural examination.² The most frequent primary oncocytic neoplasm is oncocytoma, which represents fewer than 1% of salivary gland tumors and is most common in the parotid gland. Other parotid neoplasms containing oncocytic cells include Warthin tumor (the second most common benign neoplasm of the salivary glands) and oncocytic carcinoma. There are also other nonneoplastic conditions associated with oncocytic cells, eg, oncocytic metaplasia and nodular and diffuse oncocytic hyperplasia.

Oncocytic lipoadenoma of the salivary glands is another extremely rare entity that has not yet been included in the 2005 World Health Organization histologic classification of salivary gland tumors.³ It should be added to this group of tumors. In our case, the diagnosis of oncocytic lipoadenoma of . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2008;134(4):446.
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