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Sam J. Daniel, MD, FRCSC

Arch Otolaryngol Head Neck Surg. 2008;134(3):322-323.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Patients with CHARGE (coloboma and cranial nerve abnormalities, heart malformation, choanal atresia, retardation of growth after birth and retardation of development, genital hypoplasia [underdevelopment] in males and urinary tract malformations, and ear malformations, deafness, or both) association are at high risk for swallowing and aspiration problems.¹ Pulmonary aspiration has been implicated as the most common cause of death in these patients.¹ In a recent review of CHARGE cases seen at Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 20 of 30 patients have required a tracheostomy during the first year of life. This places a tremendous burden on caregivers and puts these patients at risk for tracheostomy-related complications. Because most patients are tube fed, the bulk of the aspirate comes from their salivary secretions. While botulinum toxin has been used in older children with sialorrhea, to our knowledge, it has never been tried in newborns to . . . [Full Text of this Article]

REPORT OF A CASE

COMMENT

AUTHOR INFORMATION

Author Affiliation: Department of Otolaryngology Head and Neck Surgery, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.