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Arch Otolaryngol Head Neck Surg. 2008;134(2):216.

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Diagnosis: Solitary fibrous tumor (SFT) of the submandibular gland

Solitary fibrous tumor, a generally benign spindle cell neoplasm that originates from the visceral or parietal pleura and less commonly from other serosal surfaces, was first described by Klemperer and Rabin¹ in 1931. It was initially termed localized mesothelioma because it was believed to arise from mesothelial cells.² However, immunohistochemical evidence has revealed that the tumor has a mesenchymal and not a mesothelial phenotype. Solitary fibrous tumors express vimentin, which is a marker of mesenchymal cells, and do not express cytoplasmic keratins, which are found in mesotheliomas.² On the other hand, they have recently been described in a variety of extrapleural sites that are not associated with serosal surfaces,³ including the head and neck region. Although their occurrence in the head and neck region is very rare, some reported locations include the upper respiratory tract and major salivary glands.^4-6

The morphological appearance of SFTs is variable; however, they are often . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2008;134(2):214.
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