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Arch Otolaryngol Head Neck Surg. 2008;134(2):212.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Langerhans cell histiocytosis (LCH) of the left temporal bone

The patient was transferred to a skull base unit, where the findings of another biopsy led to the diagnosis of LCH. A whole-body bone scan showed that the disease was limited to the left temporal bone, and radiotherapy to the left side of skull was initiated.

In 1953, Lichtenstein¹ observed that eosinophilic granuloma, Hand-Schüller-Christian disease, and Letterer-Siwe disease all have similar histologic features and coined the term histiocytosis X. In 1987, the name was changed to LCH, as recommended by the Writing Group of the Histiocytosis Society.² Langerhans cell histiocytosis is a rare, proliferative disorder in which there is accumulation of pathologic Langerhans cells, causing local tissue infiltration and destruction.³ Histiocytes, which include dendritic cells and mononuclear phagocytes, are derived from bone marrow and migrate into the peripheral tissues after a period in the circulation. Langerhans cells are a subpopulation of dendritic histiocytes and are primarily located in . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2008;134(2):210.
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