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Arch Otolaryngol Head Neck Surg. 2008;134(12):1344.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Sinonasal osteosarcoma

Osteosarcoma is the most common primary malignant neoplasm of the bone, with a reported incidence of 1 per 100 000, 6% to 10% of which present with a primary tumor of the head and neck.¹ More than 500 cases have been reported in the literature. The majority of head and neck osteosarcomas involve the mandible and the maxilla, and these tumors typically carry a better prognosis than those in extragnathic locations.² Primary occurrence at the base of the skull is rare.² The pathogenesis of osteosarcoma remains unknown. The association with Paget disease of bone has been well documented, and Kansara and Thomas³ recently reviewed the molecular pathogenesis, with particular emphasis on the retinoblastoma suppressor gene and TP53 (tumor protein p53). Patel et al⁴ reported osteosarcomas arising as sequelae from previous irradiation.

The histologic features of osteosarcoma can be variable, ranging from well-differentiated lesions producing osteoid and bone to high-grade malignant neoplasms . . . [Full Text of this Article]

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