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Arch Otolaryngol Head Neck Surg. 2008;134(11):1230-1231.

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Diagnosis: Osteonecrosis of the jaw: aminobisphosphonate epidemic

Osteonecrosis is the death of a bone or a part of a bone that results as a natural consequence of a wide variety of systemic and local factors that compromise the blood flow within the bone, including hemoglobinopathies, anticardiolipin antibodies, defects of the thrombotic and fibrinolytic systems, fat emboli, alcoholism, systemic lupus erythematosus, and corticosteroid administration.¹ It simulates the ischemic condition in the heart but has also been called the coronary disease of the mandible. A few years ago, previous head and neck radiotherapy was the factor most commonly associated with mandibular osteonecrosis.

Bisphosphonates are a group of drugs that were discovered in the late 1960s for the treatment of diseases with undesirably high bone resorption rates, such as Paget disease and tumor-induced hypercalcemia, as well as for the treatment of bone metastases, eg, in cases of multiple myeloma and breast or prostate cancer. In the last several years, oral . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2008;134(11):1229.
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